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Int J Dermatol. 2008 Apr;47(4):380-2. doi: 10.1111/j.1365-4632.2008.03395.x.

Autoimmune progesterone dermatitis. Case report with histologic overlap of erythema multiforme and urticaria.

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  • 1Private Practice of Dermatology and Iowa Pathology Associates, Des Moines, Iowa, USA. hobartwalling@yahoo.com

Abstract

BACKGROUND:

Autoimmune progesterone dermatitis is a rare eruption that recurs monthly as progesterone levels peak during the menstrual cycle. Clinical and histologic features are variable, and the eruption is thought to represent a hypersensitivity response to endogenous progesterone.

METHODS:

We present the case of a 38-year-old woman with a pruritic intermittent facial eruption of 18 months' duration that recurred predictably in the days surrounding menses.

RESULTS:

The histology showed interface dermatitis with features of both erythema multiforme and urticaria. Intradermal injection of medroxyprogesterone acetate was positive. Her symptoms responded to antihistamine therapy.

CONCLUSION:

This unusual case is particularly distinctive both in terms of the histologic findings and the response to therapy.

PMID:
18377604
[PubMed - indexed for MEDLINE]
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