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Congenit Heart Dis. 2007 Mar-Apr;2(2):104-9. doi: 10.1111/j.1747-0803.2007.00081.x.

Update on randomized clinical trials impacting clinical care in pediatric cardiac intensive care.

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  • 1Division of Cardiology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.


Clinical trials addressing the management of infants and children with congenital heart disease are challenged by low numbers of patients with a similar diagnosis (inadequate power), variation in management strategies between institutions (difficulty developing multicentered protocols), a rapidly evolving field (equipoise), and insufficient funding. This article summarizes the challenges and the results of some single-center and multicenter trials evaluating perioperative care of infants and children undergoing surgery for congenital heart disease.

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