J Pediatr Hematol Oncol. 2008 Feb;30(2):179-81.

Remission of infantile generalized myofibromatosis after interferon alpha therapy.

Auriti C, Kieran MW, Deb G, Devito R, Pasquini L, Danhaive O.

Source

Department of Neonatology, Bambino Gesù Children's Hospital, Rome, Italy. auriti@opbg.net

Abstract

Infantile myofibromatosis is the most common fibrous tumor of infancy. Solitary or generalized myofibromas without visceral involvement usually regress within a few months. The multifocal disease infantile generalized myofibromatosis, with visceral involvement, is associated with a significant mortality due to the effect of tumors on vital organs. We report a case of infantile generalized myofibromatosis with visceral involvement, including 2 right atrium tumors. The infant expressed high circulating vascular endothelial growth factor and fibroblast growth factor-2 levels, and interferon alpha-2b was started as antiangiogenic treatment, aimed at triggering regression of the life-threatening cardiac lesions. The tumors regressed and vascular endothelial growth factor and fibroblast growth factor-2 levels were reduced after treatment discontinuation.

PMID:: 18376275; [PubMed - indexed for MEDLINE]

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