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Nanomedicine (Lond). 2008 Apr;3(2):201-13. doi: 10.2217/17435889.3.2.201.

Gadofullerene MRI contrast agents.

Author information

  • 1TDA Research, Inc., 12345 West 52nd Avenue, Wheat Ridge, CO 80033, USA. bolskar@tda.com.

Abstract

A promising new class of MRI contrast-enhancing agents with high relaxivities is based on gadolinium-containing metallofullerenes, which are also termed gadofullerenes. Detailed study of the water-proton relaxivity properties and intermolecular nanoclustering behavior of gadofullerene derivatives has revealed valuable information about their relaxivity mechanisms and given a deeper understanding of this new class of paramagnetic contrast agent. Here, the latest findings on water-solubilized gadofullerene materials and how these findings relate to their future applications in MRI are reviewed and discussed.

PMID:
18373426
[PubMed - indexed for MEDLINE]
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