Isoxazolone based inhibitors of p38 MAP kinases. [J Med Chem. 2008]

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1: J Med Chem. 2008 Apr 24;51(8):2580-4. Epub 2008 Mar 29. Links

Isoxazolone based inhibitors of p38 MAP kinases.

Laufer SA, Margutti S.

Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard Karls University of Tuebingen, Auf der Morgenstelle 8, 72076 Tuebingen, Germany. stefan.laufer@uni-tuebingen.de

SAR of N-alkylated isoxazolones as p38 MAP kinase inhibitors was realized. The data herein show the possibility of transferring the SAR study and evaluation from N-1-substituted imidazole to isoxazolones. Optimization of substituent was realized.

PMID: 18373337 [PubMed - indexed for MEDLINE]

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CoMFA and docking studies on triazolopyridine oxazole derivatives as p38 MAP kinase inhibitors. [Eur J Med Chem. 2008]
Synthesis and SAR of p38alpha MAP kinase inhibitors based on heterobicyclic scaffolds. [Bioorg Med Chem Lett. 2007]
Structure-activity relationships of p38 mitogen-activated protein kinase inhibitors. [Mini Rev Med Chem. 2005]
Pyrazolo-pyrimidines: a novel heterocyclic scaffold for potent and selective p38 alpha inhibitors. [Bioorg Med Chem Lett. 2008]
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Isoxazolone based inhibitors of p38 MAP kinases.

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