Send to

Choose Destination
See comment in PubMed Commons below
J Feline Med Surg. 2008 Aug;10(4):418-21. doi: 10.1016/j.jfms.2008.01.006. Epub 2008 Mar 26.

Pharmacokinetics and toxicity of zonisamide in cats.

Author information

  • 1Department of Veterinary Radiology, Nippon Veterinary and Life Science University, 1-7-1 Kyounan-chou, Musashino-shi, Tokyo 180-8602, Japan.


With the eventual goal of making zonisamide (ZNS), a relatively new antiepileptic drug, available for the treatment of epilepsy in cats, the pharmacokinetics after a single oral administration at 10mg/kg and the toxicity after 9-week daily administration of 20mg/kg/day of ZNS were studied in healthy cats. Pharmacokinetic parameters obtained with a single administration of ZNS at 10mg/day were as follows: Cmax=13.1microg/ml; Tmax=4.0h; T(1/2)=33.0h; areas under the curves (AUCs)=720.3microg/mlh (values represent the medians). The study with daily administrations revealed that the toxicity of ZNS was comparatively low in cats, suggesting that it may be an available drug for cats. However, half of the cats that were administered 20mg/kg/day daily showed adverse reactions such as anorexia, diarrhoea, vomiting, somnolence and locomotor ataxia.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk