Cell Stem Cell. 2008 Jan 10;2(1):8-9. doi: 10.1016/j.stem.2007.12.003.

Do cells let-7 determine stemness?

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Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551. pdroge@ntu.edu.sg

Abstract

During oncogenic transformation, microRNA levels of the translation-regulatory factor let-7 correlate inversely with expression of the HMGA2 oncoprotein. In a recent issue of Cell, Yu et al. (2007) now provide evidence that the let-7/HMGA2 linkage could be a signature of cancer stem cells in vivo, with broader implications for stem cell research.

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