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Cell Stem Cell. 2007 Oct 11;1(4):371-81. doi: 10.1016/j.stem.2007.09.014.

Sic transit gloria: farewell to the epidermal transit amplifying cell?

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  • 1MRC Cancer Cell Unit, Hutchison-MRC Research Centre, Cambridge CB2 0XZ, UK. phj20@hutchison-mrc.cam.ac.uk

Abstract

For the past 30 years, the prevailing model of epidermal homeostasis has been that epidermal stem cells give rise to transit amplifying cells, which undergo a limited number of cell divisions before initiating terminal differentiation. Recent studies challenge the existence of a transit amplifying cell compartment and suggest a new paradigm for epidermal homeostasis.

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