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Biochim Biophys Acta. 2008 Apr;1779(4):286-94. doi: 10.1016/j.bbagrm.2008.03.003. Epub 2008 Mar 19.

The Cid1 poly(U) polymerase.

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  • 1Sir William Dunn School of Pathology, University of Oxford, UK.


The Schizosaccharomyces pombe cytoplasmic protein Cid1 acts as a poly(U) polymerase (PUP). Polyadenylated actin mRNA, a target of this activity, is uridylated upon arrest in S phase and is likely to be one of many such Cid1 targets. This RNA uridylation pathway appears to be conserved, as Cid1 orthologs in Arabidopsis thaliana, Caenorhabditis elegans and humans display PUP activity either in vitro or in Xenopus laevis oocytes. Here, we review the literature on Cid1, other PUPs and uridylation, a conserved and previously under-appreciated mechanism of RNA regulation.

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