Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Metab Syndr Relat Disord. 2008 Mar;6(1):1-7. doi: 10.1089/met.2007.0026.

Nonalcoholic steatohepatitis and the metabolic syndrome.

Author information

  • 1Division of Gastroenterology and Hepatology, University of California Davis, Sacramento, USA.

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a major form of chronic liver disease in adults and children. It is one of the consequences of the current obesity epidemic, and can progress to nonalcoholic steatohepatitis (NASH), characterized by steatosis, inflammation, and progressive fibrosis, ultimately leading to cirrhosis and end-stage liver disease. The factors implicated in this progression are poorly understood. NASH is closely associated with obesity and the metabolic syndrome. Recent studies emphasize the role of insulin resistance, oxidative stress, lipid peroxidation, and cytokine release in the development of NASH. This review summarizes the current knowledge on the etiology and pathomechanism of NASH and the role of the metabolic syndrome in NASH development.

PMID:
18370830
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk