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Fertil Steril. 2009 Feb;91(2):365-71. doi: 10.1016/j.fertnstert.2007.11.049. Epub 2008 Mar 25.

Triggering with human chorionic gonadotropin or a gonadotropin-releasing hormone agonist in gonadotropin-releasing hormone antagonist-treated oocyte donor cycles: findings of a large retrospective cohort study.

Author information

  • 1Clínica EUGIN, Barcelona, Spain. dbodri@telefonica.net

Abstract

OBJECTIVE:

To compare pregnancy rates and the incidence of ovarian hyperstimulation syndrome (OHSS) in donor stimulation cycles where final maturation of oocytes was induced with recombinant hCG or GnRH agonist.

DESIGN:

Retrospective, cohort study.

SETTING:

Private infertility clinic.

PATIENT(S):

A total of 1171 egg donors performing 2077 stimulation cycles.

INTERVENTION(S):

Controlled ovarian hyperstimulation of egg donors with GnRH antagonist protocol triggered with recombinant hCG (rhCG; 250 microg) or GnRH agonist (triptorelin 0.2 mg) based on the physician's decision.

MAIN OUTCOME MEASURE(S):

Proportion of mature and fertilized oocytes per donor cycle; clinical, ongoing pregnancy and implantation rate in recipients; and incidence of moderate/severe OHSS in oocyte donors.

RESULT(S):

The proportion of mature oocytes was comparable, whereas the difference in the fertilization rate reached statistical significance (65% vs. 69%). No significant differences were observed in the implantation rate or clinical and ongoing pregnancy rates per ET. The incidence of moderate/severe OHSS was 1.26% (13/1031; 95% confidence interval [CI], 0.74-2.15) and 0% (0/1046; 95% CI, 0.00-0.37) in the rhCG and GnRH agonist groups, respectively.

CONCLUSION(S):

Recipient outcome was not significantly different when using oocytes from GnRH antagonist-treated donor cycles triggered with hCG or GnRH agonist. However, GnRH agonist triggering was associated with a lower incidence of moderate/severe OHSS in egg donors.

PMID:
18367175
[PubMed - indexed for MEDLINE]
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