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Urol Oncol. 2009 Mar-Apr;27(2):187-90. doi: 10.1016/j.urolonc.2007.10.015. Epub 2008 Feb 4.

Cisplatin and gemcitabine in the management of metastatic penile cancer.

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  • 1Department of Medical Oncology, St. James's Hospital, Dublin, Ireland. drdgpower@gmail.com


Penile cancer is rare and receives little public attention. There are few treatment options for advanced disease. The most active regimen to date is a combination of bleomycin, methotrexate, and cisplatin. However the treatment-related mortality is 11% and hence this combination has not been adapted as a standard of care. We report two cases of advanced penile cancer where a sustained palliative response was observed with combination chemotherapy using cisplatin and gemcitabine. Our experience demonstrates that this is a well tolerated regimen active in this setting.

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