Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nat Genet. 2008 Apr;40(4):421-9. doi: 10.1038/ng.113. Epub 2008 Mar 23.

Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids.

Author information

  • 1Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA.

Erratum in

  • Nat Genet. 2008 May;40(5):682.

Abstract

We mapped regulatory loci for nearly all protein-coding genes in mammals using comparative genomic hybridization and expression array measurements from a panel of mouse-hamster radiation hybrid cell lines. The large number of breaks in the mouse chromosomes and the dense genotyping of the panel allowed extremely sharp mapping of loci. As the regulatory loci result from extra gene dosage, we call them copy number expression quantitative trait loci, or ceQTLs. The -2log10P support interval for the ceQTLs was <150 kb, containing an average of <2-3 genes. We identified 29,769 trans ceQTLs with -log10P > 4, including 13 hotspots each regulating >100 genes in trans. Further, this work identifies 2,761 trans ceQTLs harboring no known genes, and provides evidence for a mode of gene expression autoregulation specific to the X chromosome.

PMID:
18362883
[PubMed - indexed for MEDLINE]
PMCID:
PMC3014048
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Write to the Help Desk