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Nat Genet. 2008 Apr;40(4):390-1. doi: 10.1038/ng.114. Epub 2008 Mar 23.

Evolutionary plasticity of genetic interaction networks.

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  • 1The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK.


Non-additive genetic interactions contribute to many genetic disorders, but they are extremely difficult to predict. Here we show that genetic interactions identified in yeast, unlike gene functions or protein interactions, are not highly conserved in animals. Genetic interactions are therefore unlikely to represent simple redundancy between genes or pathways, and genetic interactions from yeast do not directly predict genetic interactions in higher eukaryotes, including humans.

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