Display Settings:

Format

Send to:

Choose Destination
Bioorg Med Chem Lett. 2008 Apr 15;18(8):2675-8. doi: 10.1016/j.bmcl.2008.03.024. Epub 2008 Mar 18.

Alkyne-quinuclidine derivatives as potent and selective muscarinic antagonists for the treatment of COPD.

Author information

  • 1UCB, R&D, Chemin du Foriest, B-1420 Braine-L'Alleud, Belgium.

Abstract

SAR around alkyne-quinuclidine derivatives allowed the discovery of highly potent muscarinic antagonists displaying interesting preferential slow off-rates from the M3 receptor.

PMID:
18359633
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk