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J Clin Epidemiol. 2008 Jul;61(7):733-9. doi: 10.1016/j.jclinepi.2007.09.007. Epub 2008 Mar 21.

Health Utilities Index Mark 3 showed valid in Alzheimer disease, arthritis, and cataracts.

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  • 1Department of Public Health Sciences, School of Public Health, University of Alberta, Edmonton, Alberta, Canada.



To assess the cross-sectional construct validity of the Health Utilities Index Mark 3 (HUI3) in Alzheimer disease (AD), arthritis (AR), and cataracts (CA).


The 1996-97 Canadian National Population Health Survey for community and institution-dwelling respondents aged 40 years and above was used in the study. Adjusted means for overall and single-attribute HUI3 scores of five subgroups were compared: (1) AD only, (2) AR only, (3) CA only, (4) at least two of the three conditions, and (5) none of the three (reference group). Regression analyses were conducted for community and institutional data to obtain adjusted mean utility scores.


Of the 76 a priori hypotheses, 55 were confirmed. HUI3 was able to describe overall burdens of AD, AR, and CA as well as vision problems associated with CA, speech and cognition problems associated with AD, and ambulation and pain problems associated with AR. Adjusted mean differences in overall HUI3 scores between AD, AR, or CA only groups and reference group ranged from -0.04 to -0.42 (P<0.05); all differences were quantitatively important.


HUI3 is useful in assessing the health-related quality of life of AD, AR, and CA of those living in the community and institutions.

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