Biol Psychiatry. 1991 Oct 1;30(7):684-90.

Serum dehydroepiandrosterone sulfate in Alzheimer's disease and in multi-infarct dementia.

Näsman B, Olsson T, Bäckström T, Eriksson S, Grankvist K, Viitanen M, Bucht G.

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Department of Geriatric Medicine, Umeå University Hospital, Sweden.

Abstract

Circulating levels of dehydroepiandrosterone sulfate (DHEAS) and cortisol were studied in 86 patients with dementia; 45 with Alzheimer's disease and 41 with multi-infarct dementia. Compared to an elderly control group, after adjustment for age and sex, patients with Alzheimer's disease were found to have lower serum levels of DHEAS. We found a covariation between serum albumin and DHEAS levels, which may be of importance regarding peripheral hormone concentration in patients with dementia. These findings may provide evidence for a role of DHEAS in amnestic disorder in humans, either reflecting or contributing to the course of dementing diseases.

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