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J Am Chem Soc. 2008 Apr 16;130(15):5008-9. doi: 10.1021/ja801436j. Epub 2008 Mar 20.

Reductively labile PRINT particles for the delivery of doxorubicin to HeLa cells.

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  • 1Department of Chemistry, University of North Carolina at Chapel Hill, Caudill Laboratories CB 3290, Chapel Hill, North Carolina 27599-3290, USA.

Abstract

A Trojan horse PRINT particle composition was developed that incorporates a reductively labile cross-linker to achieve activated release of doxorubicin in vitro. Particles of discrete size and shape (cube side length = 2 micron) containing 30 wt % of a disulfide-based cross-linker and 2 wt % doxorubicin were synthesized. This PRINT composition was shown to release doxorubicin in response to a reducing environment as measured by flow cytometry and was found to be highly proficient at killing HeLa cells in vitro.

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