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Appl Opt. 2000 Dec 1;39(34):6466-86.

Instrumentation and calibration protocol for imaging dynamic features in dense-scattering media by optical tomography.

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  • 1Downstate Medical Center, State University of New York, Box 25, 450 Clarkson Avenue, Brooklyn, New York 11203, USA.


Instrumentation is described that is suitable for acquiring multisource, multidetector, time-series optical data at high sampling rates (up to 150 Hz) from tissues having arbitrary geometries. The design rationale, calibration protocol, and measured performance features are given for both a currently used, CCD-camera-based instrument and a new silicon-photodiode-based system under construction. Also shown are representative images that we reconstructed from data acquired in laboratory studies using the described CCD-based instrument.

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