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    Psychiatr Genet. 2008 Apr;18(2):47-52.

    Association study of serotonin system genes in childhood-onset mood disorder.

    Shaikh SA, Strauss J, King N, Bulgin NL, Vetró A, Kiss E, George CJ, Kovacs M, Barr CL, Kennedy JL; International Consortium for Childhood-Onset Mood Disorders.

    Source

    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Canada.

    Abstract

    BACKGROUND:

    The serotonin system has been implicated in neuropsychiatric disorders, including mood disorders.

    METHODS:

    We investigated polymorphisms in two serotonin-receptor genes, HTR1B and HTR2A, and the serotonin transporter (SLC6A4) in two independent samples of patients with childhood-onset mood disorders (COMD): 203 patients from Pittsburgh, USA with matched controls and 448 small families from Hungary.

    RESULTS:

    Case-control and family-based analyses showed no association between COMD and any of the studied polymorphisms (all P values >0.05). Haplotype analysis of SLC6A4 was also negative in both samples.

    CONCLUSIONS:

    Overall, the examination of genetic variants at the HTR1B, HTR2A, and SLC6A4 loci indicated no association between the selected polymorphisms and COMD.

    PMID:
    18349694
    [PubMed - indexed for MEDLINE]

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