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    Nature. 1991 Nov 7;354(6348):31-7.

    Molecular cloning and characterization of the rat NMDA receptor.

    Moriyoshi K, Masu M, Ishii T, Shigemoto R, Mizuno N, Nakanishi S.

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    Institute for Immunology, Kyoto University Faculty of Medicine, Japan.

    Abstract

    A complementary DNA encoding the rat NMDA receptor has been cloned and characterized. The single protein encoded by the cDNA forms a receptor-channel complex that has electrophysiological and pharmacological properties characteristic of the NMDA receptor. This protein has a significant sequence similarity to the AMPA/kainate receptors and contains four putative transmembrane segments following a large extracellular domain. The NMDA receptor messenger RNA is expressed in neuronal cells throughout the brain regions, particularly in the hippocampus, cerebral cortex and cerebellum.

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    PMID:
    1834949
    [PubMed - indexed for MEDLINE]

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