J Nat Prod. 2008 Apr;71(4):642-6. Epub 2008 Mar 19.

Steroids and flavonoids from Physalis alkekengi var. franchetii and their inhibitory effects on nitric oxide production.

Qiu L, Zhao F, Jiang ZH, Chen LX, Zhao Q, Liu HX, Yao XS, Qiu F.

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Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University 81#, No. 103 Road WenHua, Shenyang 110016, People's Republic of China.

Abstract

Four new steroidal compounds possessing a rare 13,14-seco-16,24-cycloergostane skeleton, physalin Y ( 1), physalin Z ( 2), physalin I ( 6), and physalin II ( 7), were isolated from the 80% EtOH extract of calyces from Physalis alkekengi var. franchetii together with 11 known steroids ( 3- 5 and 8- 15) and eight flavonoids ( 16- 23). The structures of the new compounds were elucidated primarily on the basis of 1D and 2D NMR and mass spectroscopic studies. The relative configuration of the 3-OH group of 3, 4, and 5 was also established or re-established. The inhibitory effects of compounds 1- 23 on nitric oxide production in lipopolysaccaride-activated macrophages were evaluated.

PMID:: 18348534; [PubMed - indexed for MEDLINE]

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J Nat Prod. 2008 Apr ;71(4):642-6. Epub 2008 Mar 19 .

PubMed
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Steroids and flavonoids from Physalis alkekengi var. franchetii and their inhibitory effects on nitric oxide production.

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