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    RNA Biol. 2007 Nov;4(3):169-72.

    Is Alba an RNase P subunit?

    Ellis JC, Barnes J, Brown JW.

    Source

    Laboratory of Signal Transduction, NIEHS, Research Triangle Park, North Carolina, USA.

    Abstract

    It has been suggested that Alba, a well-established chromatin protein in Archaea, is also a subunit of the archaeal RNase P holoenzyme, based on the observation that the homolog of this protein in humans has been shown to be associated with RNase P activity. Using the same biochemical methods we used previously to show that four other proteins homologous to eukaryotic RNase P proteins are bona fide RNase P subunits in Archaea, we could not detect any association of the Alba homolog in Methanothermobacter thermoautotrophicus (Mth1483p) with the RNase P holoenzyme. In addition, the presence of Mth1483p did not enhance the activity of RNase P holoenzyme reconstituted from recombinant subunits. In conclusion, we find no evidence that Alba is an RNase P subunit.

    PMID:
    18347433
    [PubMed - indexed for MEDLINE]
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