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Genes Dev. 2008 Mar 15;22(6):734-9. doi: 10.1101/gad.1629408.

Foxn4 directly regulates tbx2b expression and atrioventricular canal formation.

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  • 1Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, San Francisco, California 94158, USA.

Abstract

Cardiac chamber formation represents an essential evolutionary milestone that allows for the heart to receive (atrium) and pump (ventricle) blood throughout a closed circulatory system. Here, we reveal a novel transcriptional pathway between foxn4 and tbx genes that facilitates this evolutionary event. We show that the zebrafish gene slipjig, which encodes Foxn4, regulates the formation of the atrioventricular (AV) canal to divide the heart. sli/foxn4 is expressed in the AV canal, and its encoded product binds to a highly conserved tbx2 enhancer domain that contains Foxn4- and T-box-binding sites, both necessary to regulate tbx2b expression in the AV canal.

Comment in

PMID:
18347092
[PubMed - indexed for MEDLINE]
PMCID:
PMC2275426
Free PMC Article

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