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    Clin Toxicol (Phila). 2008 Mar;46(3):264-6.

    A case of 5-fluorouracil-induced peripheral neuropathy.

    Werbrouck BF, Pauwels WJ, De Bleecker JL.

    Source

    Department of Neurology, Ghent University Hospital, Ghent, Belgium.

    Abstract

    The standard adjuvant therapy for rectal cancer is 5-fluorouracil (5-FU) often combined with radiotherapy. Well-documented side effects of 5-FU include nausea, vomiting and diarrhoea, leukopenia and thrombocytopenia, hand-foot syndrome, mucositis, and cardiotoxicity. Peripheral neurotoxicity has only rarely been reported. We report a patient with a stage II rectal carcinoma who developed a mild axonal sensorimotor neuropathy at the end of a 5-FU therapy.

    PMID:
    18344111
    [PubMed - indexed for MEDLINE]

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