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    Bioorg Med Chem Lett. 2008 Apr 1;18(7):2373-6. Epub 2008 Mar 4.

    Synthesis of barbiturate-based methionine aminopeptidase-1 inhibitors.

    Haldar MK, Scott MD, Sule N, Srivastava DK, Mallik S.

    Department of Pharmaceutical Sciences, North Dakota State University, 1401 Albrecht Boulevard, Fargo, ND 58105, USA.

    The syntheses of a new class of barbiturate-based inhibitors for human and Escherichia Coli methionine aminopeptidase-1 (MetAP-1) are described. Some of the synthesized inhibitors show selective inhibition of the human enzyme with high potency.

    PMID: 18343108 [PubMed - indexed for MEDLINE]

    PMCID: 2390822

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