Solid-phase synthesis of oligomers carrying severa...[Bioorg Med Chem Lett. 2008]

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1: Bioorg Med Chem Lett. 2008 Apr 1;18(7):2306-10. Epub 2008 Mar 5. Links

Solid-phase synthesis of oligomers carrying several chromophore units linked by phosphodiester backbones.

Aviñó A, Navarro I, Farrera-Sinfreu J, Royo M, Aymamí J, Delgado A, Llebaria A, Albericio F, Eritja R.

Institute for Research in Biomedicine (IRB Barcelona), Josep Samitier 1-5, E-08028 Barcelona, Spain.

A method for the preparation of oligomers by linking chromophore units is described. Specifically, the synthesis of chromophore units having a protected-hydroxyl group and a phosphoramidite function is described, along with a method to link several units using solid-phase phosphite-triester protocols.

PMID: 18343107 [PubMed - indexed for MEDLINE]

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Solid-phase synthesis of oligomers carrying several chromophore units linked by phosphodiester backbones.

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