Brain Res. 1991 Jul 26;555(1):159-63.

Cerebrovascular and functional consequences of 5-HT1A receptor activation.

McBean DE, Sharkey J, Ritchie IM, Kelly PA.

Source

Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, U.K.

Abstract

Cerebral glucose utilization and blood flow were measured in rats using 2-deoxy-D-[14C]glucose and [14C]iodoantipyrine quantitative autoradiography, respectively, following treatment with the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT). In control and 8-OH-DPAT-treated animals blood flow and glucose use were similarly correlated, but the ratio was increased following 8-OH-DPAT treatment. Since 5-HT1A receptor activation is known to reduce neuronal 5-HT release, these results are consistent with a vasoconstrictor role for endogenous serotonin.

PMID:: 1834308; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Elsevier Science

Molecular Biology Databases

GLUCOSE - HSDB

Supplemental Content

Save items

Related citations in PubMed

Acute administration of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a selective 5-HT-receptor agonist, causes a biphasic blood pressure response and a bradycardia in the normotensive Sprague-Dawley rat and in the spontaneously hypertensive rat. [J Neural Transm. 1985]
Acute administration of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a selective 5-HT-receptor agonist, causes a biphasic blood pressure response and a bradycardia in the normotensive Sprague-Dawley rat and in the spontaneously hypertensive rat.
Gradin K, Pettersson A, Hedner T, Persson B. J Neural Transm. 1985; 62(3-4):305-19.
Cardiovascular and adrenaline-releasing effects of the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin in streptozotocin diabetic rats. [Life Sci. 1991]
Cardiovascular and adrenaline-releasing effects of the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin in streptozotocin diabetic rats.
Chaouloff F, Blanc J, Baudrie V, Laude D, Elghozi JL. Life Sci. 1991; 48(26):2543-52.
Mediation of the discriminative stimulus properties of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) by the putative 5-HT1A receptor. [Eur J Pharmacol. 1987]
Mediation of the discriminative stimulus properties of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) by the putative 5-HT1A receptor.
Tricklebank MD, Neill J, Kidd EJ, Fozard JR. Eur J Pharmacol. 1987 Jan 6; 133(1):47-56.
Cardiovascular response to 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) in the rat: site of action and pharmacological analysis. [J Cardiovasc Pharmacol. 1987]
Cardiovascular response to 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) in the rat: site of action and pharmacological analysis.
Fozard JR, Mir AK, Middlemiss DN. J Cardiovasc Pharmacol. 1987 Mar; 9(3):328-47.
Repeated treatment with the 5-HT1A receptor agonist, ipsapirone, does not affect 8-OH-DPAT- and stress-induced increases in plasma adrenaline levels in the rat. [Eur J Pharmacol. 1991]
Repeated treatment with the 5-HT1A receptor agonist, ipsapirone, does not affect 8-OH-DPAT- and stress-induced increases in plasma adrenaline levels in the rat.
Baudrie V, Chaouloff F. Eur J Pharmacol. 1991 Jun 6; 198(2-3):129-35.

See reviews... See all...

Cited by 1 PubMed Central article

Brain aging research at the close of the 20th century: from bench to bedside. [Dialogues Clin Neurosci. 2001]
Brain aging research at the close of the 20th century: from bench to bedside.
Cidis Meltzer C, Francis PT. Dialogues Clin Neurosci. 2001 Sep; 3(3):167-80.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Cerebrovascular and functional consequences of 5-HT1A receptor activation.
Cerebrovascular and functional consequences of 5-HT1A receptor activation.
Brain Res. 1991 Jul 26 ;555(1):159-63.

PubMed
Outcomes of high pretest probability patients undergoing d-dimer testing for pul...
Outcomes of high pretest probability patients undergoing d-dimer testing for pulmonary embolism: a pilot study.
J Emerg Med. 2008 Nov ;35(4):373-7. Epub 2008 Mar 17 .

PubMed
Extracellular gadolinium contrast agents: differences in stability.
Extracellular gadolinium contrast agents: differences in stability.
Eur J Radiol. 2008 May ;66(2):175-9. Epub 2008 Mar 14 .

PubMed
Predictors of involvement in the juvenile justice system among psychiatric hospi...
Predictors of involvement in the juvenile justice system among psychiatric hospitalized adolescents.
Addict Behav. 2008 Jul ;33(7):942-8. Epub 2008 Feb 23 .

PubMed
A phase I/II study of direct intraarterial (ophthalmic artery) chemotherapy with...
A phase I/II study of direct intraarterial (ophthalmic artery) chemotherapy with melphalan for intraocular retinoblastoma initial results.
Ophthalmology. 2008 Aug ;115(8):1398-404, 1404.e1. Epub 2008 Mar 14 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Cerebrovascular and functional consequences of 5-HT1A receptor activation.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 1 PubMed Central article

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information