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J Biol. 2008;7(3):8. doi: 10.1186/jbiol70. Epub 2008 Mar 7.

A Caenorhabditis elegans genetic-interaction map wiggles into view.

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  • 1Center for Genomics and Systems Biology and Department of Biology, New York University, 1009 Silver Center, 100 Washington Square East, New York, NY 10003, USA. kcg1@nyu.edu

Abstract

Systematic mapping of genetic-interaction networks will provide an essential foundation for understanding complex genetic disorders, mechanisms of genetic buffering and principles of robustness and evolvability. A recent study of signaling pathways in Caenorhabditis elegans lays the next row of bricks in this foundation.

PMID:
18341704
[PubMed - indexed for MEDLINE]
PMCID:
PMC2323036
Free PMC Article
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