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1: Genome Biol. 2008;9(3):213. Epub 2008 Mar 4.Click here to read Click here to read Links

On the nature of thumbs.

Wagner GP, Vargas AO.

Department of Ecology and Evolutionary Biology, Yale University, Prospect Street, New Haven, CT 06520-8106, USA. gunter.wagner@yale.edu

Asymmetric regulation of Hox gene expression pre-dates the appearance of tetrapod digits, and was co-opted in the development of 'thumbness'. This asymmetric expression correlates with independent morphological evolutionary variation of digit 1.

PMID: 18341703 [PubMed - indexed for MEDLINE]

PMCID: PMC2397496

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