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1: Am J Gastroenterol. 2008 Mar;103(3):628-30.Click here to read Links
Comment on:
Am J Gastroenterol. 2008 Mar;103(3):615-20.
Am J Gastroenterol. 2008 Mar;103(3):621-7.

IL23R and ATG16L1 SNPs in IBD: alphabet soup or something more?

Achkar JP.

The results of recently completed genome-wide association studies have rapidly advanced knowledge of inflammatory bowel disease (IBD) genetics. Several promising associations between IBD and gene variants have been identified with the two best replicated so far being variants in the IL23R and ATG16L1 genes. These findings highlight the importance of the immune system and interactions with intestinal microflora in the pathogenesis of IBD.

PMID: 18341487 [PubMed - indexed for MEDLINE]