J Am Chem Soc. 2008 Apr 9;130(14):4604-6. Epub 2008 Mar 15.

Manganous phosphate acts as a superoxide dismutase.

Barnese K, Gralla EB, Cabelli DE, Valentine JS.

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Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095-1569, USA.

Abstract

A substantial body of evidence indicates that high intracellular concentrations of inorganic manganous ions render some cells resistant to ionizing radiation and provide substantial antioxidant protection to aerobic cells lacking superoxide dismutase (SOD) enzymes. We found that manganous phosphate is unique among those manganous salts studied in its ability to remove superoxide rapidly and catalytically from aqueous solution via a disproportionation mechanism that is entirely different from those of the SOD enzymes.

PMID:: 18341341; [PubMed - indexed for MEDLINE]

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