Nat Rev Microbiol. 2008 Apr;6(4):288-301.

The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease.

Kadioglu A, Weiser JN, Paton JC, Andrew PW.

Source

Department of Infection, Immunity & Inflammation, University of Leicester, Leicester LE1 9HN, United Kingdom. ak13@leicester.ac.uk

Abstract

Streptococcus pneumoniae is a Gram-positive bacterial pathogen that colonizes the mucosal surfaces of the host nasopharynx and upper airway. Through a combination of virulence-factor activity and an ability to evade the early components of the host immune response, this organism can spread from the upper respiratory tract to the sterile regions of the lower respiratory tract, which leads to pneumonia. In this Review, we describe how S. pneumoniae uses its armamentarium of virulence factors to colonize the upper and lower respiratory tracts of the host and cause disease.

PMID:: 18340341; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

Virulence Factors

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Pneumococcal Infections - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Contributions of pneumolysin, pneumococcal surface protein A (PspA), and PspC to pathogenicity of Streptococcus pneumoniae D39 in a mouse model. [Infect Immun. 2007]
Contributions of pneumolysin, pneumococcal surface protein A (PspA), and PspC to pathogenicity of Streptococcus pneumoniae D39 in a mouse model.
Ogunniyi AD, LeMessurier KS, Graham RM, Watt JM, Briles DE, Stroeher UH, Paton JC. Infect Immun. 2007 Apr; 75(4):1843-51. Epub 2007 Jan 29.
Upper and lower respiratory tract infection by Streptococcus pneumoniae is affected by pneumolysin deficiency and differences in capsule type. [Infect Immun. 2002]
Upper and lower respiratory tract infection by Streptococcus pneumoniae is affected by pneumolysin deficiency and differences in capsule type.
Kadioglu A, Taylor S, Iannelli F, Pozzi G, Mitchell TJ, Andrew PW. Infect Immun. 2002 Jun; 70(6):2886-90.
Review Streptococcus pneumoniae: virulence factors and variation. [Clin Microbiol Infect. 2010]
Review Streptococcus pneumoniae: virulence factors and variation.
Mitchell AM, Mitchell TJ. Clin Microbiol Infect. 2010 May; 16(5):411-8. Epub 2010 Feb 2.
Regions of Diversity 8, 9 and 13 contribute to Streptococcus pneumoniae virulence. [BMC Microbiol. 2007]
Regions of Diversity 8, 9 and 13 contribute to Streptococcus pneumoniae virulence.
Embry A, Hinojosa E, Orihuela CJ. BMC Microbiol. 2007 Aug 27; 7:80. Epub 2007 Aug 27.
Review The pneumococcus: why a commensal misbehaves. [J Mol Med (Berl). 2010]
Review The pneumococcus: why a commensal misbehaves.
Weiser JN. J Mol Med (Berl). 2010 Feb; 88(2):97-102. Epub 2009 Nov 7.

See reviews... See all...

Cited by 66 PubMed Central articles

Chemical inhibition of bacterial protein tyrosine phosphatase suppresses capsule production. [PLoS One. 2012]
Chemical inhibition of bacterial protein tyrosine phosphatase suppresses capsule production.
Standish AJ, Salim AA, Zhang H, Capon RJ, Morona R. PLoS One. 2012; 7(5):e36312. Epub 2012 May 15.
Transcriptional Portrait of Actinobacillus pleuropneumoniae during Acute Disease - Potential Strategies for Survival and Persistence in the Host. [PLoS One. 2012]
Transcriptional Portrait of Actinobacillus pleuropneumoniae during Acute Disease - Potential Strategies for Survival and Persistence in the Host.
Klitgaard K, Friis C, Jensen TK, Angen O, Boye M. PLoS One. 2012; 7(4):e35549. Epub 2012 Apr 17.
Role of fibronectin in the adhesion of Acinetobacter baumannii to host cells. [PLoS One. 2012]
Role of fibronectin in the adhesion of Acinetobacter baumannii to host cells.
Smani Y, McConnell MJ, Pachón J. PLoS One. 2012; 7(4):e33073. Epub 2012 Apr 13.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The role of Streptococcus pneumoniae virulence factors in host respiratory colon...
The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease.
Nat Rev Microbiol. 2008 Apr ;6(4):288-301.

PubMed
United States Pharmacopeia review of the black cohosh case reports of hepatotoxi...
United States Pharmacopeia review of the black cohosh case reports of hepatotoxicity.
Menopause. 2008 Jul-Aug ;15(4 Pt 1):628-38.

PubMed
Dysfunctional attitudes and cognitive schemas in bipolar manic and unipolar depr...
Dysfunctional attitudes and cognitive schemas in bipolar manic and unipolar depressed outpatients: implications for cognitively based psychotherapeutics.
J Nerv Ment Dis. 2008 Mar ;196(3):207-10.

PubMed
Middle cerebral artery occlusion in the rabbit using selective angiography: appl...
Middle cerebral artery occlusion in the rabbit using selective angiography: application for assessment of thrombolysis.
Stroke. 2008 May ;39(5):1613-5. Epub 2008 Mar 13 .

PubMed
Don't add aspirin for associated stable vascular disease in a patient with atria...
Don't add aspirin for associated stable vascular disease in a patient with atrial fibrillation receiving anticoagulation.
BMJ. 2008 Mar 15 ;336(7644):614-5.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: