Circ Res. 2008 Mar 14;102(5):519-28.

Mechanisms underlying caloric restriction and lifespan regulation: implications for vascular aging.

Ungvari Z, Parrado-Fernandez C, Csiszar A, de Cabo R.

Source

Department of Physiology, New York Medical College, Valhalla, USA.

Abstract

This review focuses on the emerging evidence that attenuation of the production of reactive oxygen species and inhibition of inflammatory pathways play a central role in the antiaging cardiovascular effects of caloric restriction. Particular emphasis is placed on the potential role of the plasma membrane redox system in caloric restriction-induced pathways responsible for sensing oxidative stress and increasing cellular oxidative stress resistance. We propose that caloric restriction increases bioavailability of NO, decreases vascular reactive oxygen species generation, activates the Nrf2/antioxidant response element pathway, inducing reactive oxygen species detoxification systems, exerts antiinflammatory effects, and, thereby, suppresses initiation/progression of vascular disease that accompany aging.

PMID:: 18340017; [PubMed - indexed for MEDLINE]
PMCID:: PMC2424221

Free PMC Article

Images from this publication.See all images (2) Free text

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Reactive Oxygen Species

Grant Support

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Review Cardiovascular determinants of life span. [Pflugers Arch. 2010]
Review Cardiovascular determinants of life span.
Shi Y, Camici GG, Lüscher TF. Pflugers Arch. 2010 Jan; 459(2):315-24. Epub 2009 Sep 12.
Review Mitochondrial oxidative stress, aging and caloric restriction: the protein and methionine connection. [Biochim Biophys Acta. 2006]
Review Mitochondrial oxidative stress, aging and caloric restriction: the protein and methionine connection.
Pamplona R, Barja G. Biochim Biophys Acta. 2006 May-Jun; 1757(5-6):496-508. Epub 2006 Feb 24.
Review Ageing, oxidative stress, and mitochondrial uncoupling. [Acta Physiol Scand. 2004]
Review Ageing, oxidative stress, and mitochondrial uncoupling.
Harper ME, Bevilacqua L, Hagopian K, Weindruch R, Ramsey JJ. Acta Physiol Scand. 2004 Dec; 182(4):321-31.
Review Mitochondria, reactive oxygen species, and chronological aging: a message from yeast. [Exp Gerontol. 2011]
Review Mitochondria, reactive oxygen species, and chronological aging: a message from yeast.
Pan Y. Exp Gerontol. 2011 Nov; 46(11):847-52. Epub 2011 Aug 22.
Influence of aging and long-term caloric restriction on oxygen radical generation and oxidative DNA damage in rat liver mitochondria. [Free Radic Biol Med. 2002]
Influence of aging and long-term caloric restriction on oxygen radical generation and oxidative DNA damage in rat liver mitochondria.
López-Torres M, Gredilla R, Sanz A, Barja G. Free Radic Biol Med. 2002 May 1; 32(9):882-9.

See reviews... See all...

Cited by 21 PubMed Central articles

Signaling and Damaging Functions of Free Radicals in Aging-Free Radical Theory, Hormesis, and TOR. [Aging Dis. 2010]
Signaling and Damaging Functions of Free Radicals in Aging-Free Radical Theory, Hormesis, and TOR.
Afanas'ev I. Aging Dis. 2010 Oct; 1(2):75-88. Epub 2010 Jul 12.
Polyhydroxy fullerenes (fullerols or fullerenols): beneficial effects on growth and lifespan in diverse biological models. [PLoS One. 2011]
Polyhydroxy fullerenes (fullerols or fullerenols): beneficial effects on growth and lifespan in diverse biological models.
Gao J, Wang Y, Folta KM, Krishna V, Bai W, Indeglia P, Georgieva A, Nakamura H, Koopman B, Moudgil B. PLoS One. 2011; 6(5):e19976. Epub 2011 May 27.
The effect of caloric restriction and glycemic load on measures of oxidative stress and antioxidants in humans: results from the CALERIE Trial of Human Caloric Restriction. [J Nutr Health Aging. 2011]
The effect of caloric restriction and glycemic load on measures of oxidative stress and antioxidants in humans: results from the CALERIE Trial of Human Caloric Restriction.
Meydani M, Das S, Band M, Epstein S, Roberts S. J Nutr Health Aging. 2011 Jun; 15(6):456-60.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Mechanisms underlying caloric restriction and lifespan regulation: implications ...
Mechanisms underlying caloric restriction and lifespan regulation: implications for vascular aging.
Circ Res. 2008 Mar 14 ;102(5):519-28.

PubMed
Caprylic acid supplemented in feed reduces enteric Campylobacter jejuni coloniza...
Caprylic acid supplemented in feed reduces enteric Campylobacter jejuni colonization in ten-day-old broiler chickens.
Poult Sci. 2008 Apr ;87(4):800-4.

PubMed
Part I: twenty-year literature overview of veterinary and allopathic medicine.
Part I: twenty-year literature overview of veterinary and allopathic medicine.
J Vet Med Educ. 2008 Spring ;35(1):66-73.

PubMed
Systems biology. Customized signaling circuits.
Systems biology. Customized signaling circuits.
Science. 2008 Mar 14 ;319(5869):1489-90.

PubMed
Biomedical research. $300 million in private money for new investigators.
Biomedical research. $300 million in private money for new investigators.
Science. 2008 Mar 14 ;319(5869):1469.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: