Cancer Res. 2008 Mar 15;68(6):1614-7.

Tumor-specific T-cell memory: clearing the regulatory T-cell hurdle.

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Department of Microbiology and Immunology, Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA.

Abstract

Antitumor immune responses can be stimulated by interfering with regulatory T-cell (T(reg)) function. However, this effect is short lived unless T-cell memory to tumor antigens can be generated. Our recent studies show that T(reg) cells not only limit primary responses to tumor/self-antigens in tumor-bearing hosts but also prevent the natural generation of T-cell memory to such antigens. Here, we discuss the role of T(reg) cells in suppressing T-cell memory after surgical excision of tumors and the potential clinical benefits of overcoming this suppression.

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PMCID: PMC2682528

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Tumor-specific T-cell memory: clearing the regulatory T-cell hurdle.

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