Transplantation. 2008 Mar 15;85(5):667-9.

Indirect allorecognition: not simple but effective.

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NIHR Biomedical Research Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK. emb34@cam.ac.uk

Abstract

Donor dendritic cells are potent but short-lived stimulators of early transplant rejection, and recipient antigen presenting cells presenting donor major histocompatibility complex peptides sustain immunoreactivity and contribute to chronic rejection. We briefly consider how CD4 T cells that recognize allopeptide can provide help for effector and regulatory responses and highlight the implications for promoting graft survival.

PMID:: 18337656; [PubMed - indexed for MEDLINE]

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Review Pathways of allorecognition: implications for transplantation tolerance. [Transpl Immunol. 2002]
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