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    QJM. 2008 Jun;101(6):475-7. Epub 2008 Mar 12.

    High rate of maternal vitamin B12 deficiency nearly a decade after Canadian folic acid flour fortification.

    Ray JG, Goodman J, O'Mahoney PR, Mamdani MM, Jiang D.

    Source

    Department of Medicine, St Michael's Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada. rayj@smh.toronto.on.ca

    Abstract

    Vitamin B12 deficiency may be an independent risk factor for neural tube defects (NTD). We determined the prevalence of biochemical B12 deficiency (<125 pmol/l) among 10 622 Ontarian women aged 15-46 years who underwent concomitant testing of serum bhCG and B12 9 years after the implementation of Canadian folic acid flour fortification. The overall prevalence of biochemical B12 deficiency was 7.4%. Relative to non-pregnant women, the adjusted odds ratio (95% confidence interval) of biochemical B12 deficiency was 0.78 (0.60-1.0) among women pregnant 28 days gestation or less and was 1.4 (1.1-1.8) after 28 days gestation. About 1 in 20 women may be deficient in B12 in early pregnancy. The impact on maternal and fetal well-being, including preventable NTD, should be considered.

    PMID:
    18337285
    [PubMed - indexed for MEDLINE]
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