Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Endocrinol Metab. 2008 May-Jun;19(4):122-9. doi: 10.1016/j.tem.2007.12.002. Epub 2008 Mar 11.

Urocortins: emerging metabolic and energy homeostasis perspectives.

Author information

  • 1Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel.

Abstract

The effects of stress on energy balance and the involvement of the neuropeptide corticotropin releasing factor in modulating the anorexia of stress and sympathetic nervous system tone are well recognized. Currently, studies centered on the roles of the more recently described members of this family of ligands, the urocortins, and their preferred receptor, the corticotropin releasing factor type 2 receptor, suggest that they are important modulators of centrally controlled metabolic functions. In addition, urocortins also regulate fuel utilization in the periphery by acting locally within key metabolic tissues through autocrine and/or paracrine mechanisms. Recent findings have demonstrated that urocortin 2 and urocortin 3, by acting through their specific receptor in peripheral tissues, are novel modulators of glucose homeostasis and metabolic functions.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk