Format

Send to:

Choose Destination
See comment in PubMed Commons below
Andrologia. 2008 Apr;40(2):134-7. doi: 10.1111/j.1439-0272.2007.00831.x.

Proliferative inflammatory atrophy: a background lesion of prostate cancer?

Author information

  • 1Institute of Pathology, University of Giessen and Marburg, Giessen, Germany.

Abstract

Proliferative inflammatory atrophy (PIA) belongs to the atrophic lesions that frequently occur in the prostate. The location of PIA in the periphery of the gland near to prostate carcinoma or even showing direct transition to malignant or pre-malignant epithelia suggested a connection between PIA and prostate cancer. Further findings in PIA, such as imbalance between proliferation and apoptosis and detection of molecular-biological abnormalities specific for oxidative stress or malignancy, supported this hypothesis. Recently, epidemiological studies including large cohorts of patients have been undertaken in order to investigate the causal connection between PIA and prostate carcinoma. The current understanding of PIA allows us to consider it as a benign lesion with certain genetic instability which can degenerate into prostate intraepithelial neoplasia or carcinoma, provided that the balance between anti-carcinogens and carcinogens is perturbed. To evaluate the role of PIA as a precursor lesion of prostate cancer, further examinations of genetic or epigenetic aberrations are required.

PMID:
18336466
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Blackwell Publishing
    Loading ...
    Write to the Help Desk