In vitro analysis of cisplatin functionalized magnetic nanoparticles in combined cancer chemotherapy and electromagnetic hyperthermia

M Babincov; V Altanerov; C Altaner; C Bergemann; P Babinec

doi:10.1109/TNB.2008.2000145

In vitro analysis of cisplatin functionalized magnetic nanoparticles in combined cancer chemotherapy and electromagnetic hyperthermia

IEEE Trans Nanobioscience. 2008 Mar;7(1):15-9. doi: 10.1109/TNB.2008.2000145.

Authors

M Babincov¹, V Altanerov, C Altaner, C Bergemann, P Babinec

Affiliation

¹ Department of Nuclear Physics and Biophysics, Comenius University, Bratislava, Slovakia. babincova@fmph.uniba.sk

PMID: 18334449
DOI: 10.1109/TNB.2008.2000145

Abstract

A novel platform has been developed for combined cancer chemotherapy and hyperthermia based on iron oxide magnetic nanoparticles functionalized with cis-diamminedichloroplatinum(II) (cisplatin). The capabilities of this system for heating and controlled drug release were investigated, and the system was tested in vitro by the treatment of BP6 rat sarcoma cells, where we demonstrated a synergism between the effects of cisplatin-targetMAG nanoparticles and the application of electromagnetic field.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / administration & dosage
Cell Line, Tumor
Cisplatin / administration & dosage*
Combined Modality Therapy
Drug Carriers / administration & dosage*
Drug Carriers / chemistry
Drug Therapy / methods
Hyperthermia, Induced / methods*
Magnetics / therapeutic use*
Nanoparticles / administration & dosage*
Nanoparticles / chemistry
Rats
Sarcoma / pathology*
Sarcoma / therapy*
Treatment Outcome

Substances

Antineoplastic Agents
Drug Carriers
Cisplatin