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Curr Biol. 2008 Mar 11;18(5):R207-9. doi: 10.1016/j.cub.2008.01.014.

Evolutionary biology: genomic clues to original sex in fungi.

Author information

  • School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, UK. Paul.Dyer@Nottingham.ac.uk


Sexual identity in fungi is conferred by a diverse group of transcription factors. Analysis of a Zygomycota genome, representing a basal branch within the fungi, indicates that HMG-domain proteins were present as ancestral sex determinants and suggests a mechanism for the evolution of eukaryotic sex chromosomes.

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