Format

Send to

Choose Destination
See comment in PubMed Commons below
Chemotherapy. 2008;54(2):152-6. doi: 10.1159/000119707. Epub 2008 Mar 7.

Antimicrobial activities of twenty lysine-peptoid hybrids against clinically relevant bacteria and fungi.

Author information

  • 1Department of Natural Sciences, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark.

Abstract

BACKGROUND:

This paper describes the antimicrobial activities of 20 lysine-peptoid hybrids against a selection of clinically relevant bacteria and fungi.

METHODS:

Minimal inhibitory concentrations were determined against methicillin-susceptible Staphylococcus aureus (ATCC 29213), methicillin-resistant S. aureus (ATCC 33591), vancomycin-intermediate S. aureus (ATCC 700699 MU50), vancomycin-resistant Enterococcus faecium (ATCC 700221), Pseudomonas aeruginosa (ATCC 27853), Salmonella typhimurium (clinical isolate), Klebsiella pneumoniae (clinical isolate), amphotericin-B-resistant C. albicans (ATCC 200955) and Cryptococcus neoformans (clinical isolate).

RESULTS:

The lysine-peptoid hybrids proved to be active against all strains tested, except K. pneumoniae. For each susceptible strain, we identified at least 4 lysine-peptoid hybrids showing excellent activity. The most active compounds displayed minimal inhibitory concentrations ranging from < or =1.6 to 6.25 microM.

CONCLUSION:

This study demonstrates that lysine-peptoid hybrids show activity against drug-resistant pathogens.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for S. Karger AG, Basel, Switzerland
    Loading ...
    Write to the Help Desk