Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Pathophysiol Haemost Thromb. 2007;36(1):40-4. doi: 10.1159/000112638. Epub 2008 Mar 6.

Reverse effect of aspirin: is the prothrombotic effect after aspirin discontinuation mediated by cyclooxygenase 2 inhibition?

Author information

  • 1Laboratoire d'H√©matologie, UFR des Sciences Pharmaceutiques, Universit√© Victor Segalen Bordeaux 2, Bordeaux, France. Christian.Doutremepuich@heph.u-bordeaux2.fr

Abstract

BACKGROUND:

While aspirin is the drug most often used to prevent cardiovascular complications, its discontinuation induces an increased risk of acute coronary syndrome and ischemic stroke in some patients.

OBJECTIVES:

We hypothesized that infinitesimal concentrations of aspirin could persist in plasma after its discontinuation, thereby inducing a prothrombotic effect that could be due to a modification in the mechanism of action of aspirin via the cyclooxygenase 1 (COX-1) and COX-2 pathways.

METHODS AND RESULTS:

We studied the effects of ultra-low-dose aspirin (ULDA) as well as those of sc-560 and ns-398, specific COX-1 and COX-2 inhibitors, on induced hemorrhagic time and in a model of laser-induced thrombosis in rats. In the laser-induced thrombosis model, ULDA treatment increased the number of emboli and the duration of embolization, thereby confirming its prothrombotic effect described in previous publications. This effect was also observed in rats pretreated with sc-560 but not in those pretreated with ns-398.

CONCLUSIONS:

We demonstrated that ULDA induced a prothrombotic effect in the rats studied. This strongly suggests that a very small amount of aspirin could remain in the patient's blood after aspirin therapy, leading to cardiovascular complications. This effect may be mediated by the COX-2 pathway.

Copyright 2008 S. Karger AG, Basel.

PMID:
18332613
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for S. Karger AG, Basel, Switzerland
    Loading ...
    Write to the Help Desk