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Fertil Steril. 2009 Apr;91(4):1175-82. doi: 10.1016/j.fertnstert.2008.01.035. Epub 2008 Mar 10.

Comparison of hormonal and metabolic markers after a high-fat, Western meal versus a low-fat, high-fiber meal in women with polycystic ovary syndrome.

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  • 1The Huck Institutes of the Life Sciences, Hershey, Pennsylvania, USA.

Abstract

OBJECTIVE:

To determine the effect of meal composition on postprandial T levels in women with polycystic ovary syndrome (PCOS).

DESIGN:

Randomized, crossover design.

SETTING:

Academic research center.

PATIENT(S):

Fifteen women with PCOS.

INTERVENTION(S):

We evaluated changes in T, sex hormone binding globulin (SHBG), DHEAS, cortisol, glucose, and insulin for 6 hours after a high-fat, Western meal (HIFAT) (62% fat, 24% carbohydrate, 1 g fiber) and an isocaloric low-fat, high-fiber meal (HIFIB) (6% fat, 81% carbohydrate, 27 g fiber).

MAIN OUTCOME MEASURE(S):

Change in T levels.

RESULT(S):

Testosterone decreased 27% within 2 hours after both meals. However, T remained below premeal values for 4 hours after the HIFIB meal and 6 hours after the HIFAT meal. Insulin was twofold higher for 2 hours after the HIFIB meal compared with the HIFAT meal. Glucose was higher for 1 hour after the HIFIB meal compared with the HIFAT meal. DHEAS decreased 8%-10% within 2-3 hours after both meals, then increased during the remainder of the study period. Cortisol decreased during the 6-hour period after both meals.

CONCLUSIONS:

Diet plays a role in the regulation of T levels in women with PCOS. Further studies are needed to determine the role of diet composition in the treatment of PCOS.

PMID:
18331737
[PubMed - indexed for MEDLINE]
PMCID:
PMC2677685
Free PMC Article

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