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Trends Neurosci. 2008 Apr;31(4):183-91. doi: 10.1016/j.tins.2008.01.004. Epub 2008 Mar 10.

Stress, sensitive periods and maturational events in adolescent depression.

Author information

  • 1Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA. sandersen@mclean.harvard.edu

Abstract

In this paper, we provide an overview of how the maturation of specific brain regions and stress exposure during windows of vulnerability initiate a series of events that render adolescents exceptionally susceptible to the development of depression. This stress-incubation/corticolimbic development cascade provides a means of understanding why depression emerges with such force and frequency in adolescence. The development of the prefrontal cortex, hippocampus, amygdala and ventral striatum is described from a translational perspective as they relate to stress exposure, onset, pathogenesis and gender differences in depression. Adolescent depression is a serious recurrent brain-based disorder. Understanding the genesis and neurobiological basis is important in the development of more effective intervention strategies to treat or prevent the disorder.

PMID:
18329735
[PubMed - indexed for MEDLINE]
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