Display Settings:

Format

Send to:

Choose Destination
Trends Neurosci. 2008 Apr;31(4):192-8. doi: 10.1016/j.tins.2008.01.006. Epub 2008 Mar 10.

Combining growth factor and stem cell therapy for amyotrophic lateral sclerosis.

Author information

  • 1The Waisman Center and Departments of Anatomy and Neurology, University of Wisconsin-Madison, Madison, WI 53707-2280, USA.

Abstract

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease where motor neurons within the brain and spinal cord are lost, leading to paralysis and death. Certain growth factors should, in principle, be able to protect dying motor neurons. However, targeted delivery to the spinal cord or brain has been a constant problem. There is also accumulating evidence that glial cells might play a crucial role in maintaining motor neuron function and survival in ALS. Stem cells isolated and expanded in culture can be modified to release growth factors and generate glial cells following transplantation into the spinal cord or brain. As such, they might be able to both detoxify the local environment around dying motor neurons and deliver trophic factors. Here we examine the feasibility of translating these findings into new treatments for ALS patients.

PMID:
18329734
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk