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J Allergy Clin Immunol. 2008 Mar;121(3):646-51. doi: 10.1016/j.jaci.2007.12.1149.

Sensitization does not develop in utero.

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  • 1Danish Pediatric Asthma Center, Department of Pediatrics, Copenhagen University Hospital, Copenhagen, Denmark. kb@copsac.dk

Abstract

BACKGROUND:

Intrauterine sensitization has been suggested to play a role in the development of atopic disease in children, and this has led to current guidelines recommending allergen avoidance during pregnancy.

OBJECTIVE:

To investigate the relevance of allergen-specific IgE in cord blood to sensitization in early infancy and the origin of such IgE.

METHODS:

Inhalant and food allergen-specific IgE in cord blood was analyzed and compared with specific IgE in infant blood at 6 months of age and in parental blood. Cord blood IgA was measured to detect maternal blood contamination of cord blood.

RESULTS:

Allergen-specific IgE, primarily against inhalant allergens, was detected in 14% of cord blood samples. However, corresponding specific IgE was not found in infant blood at 6 months of age. Specific IgE in cord blood completely matched specific IgE in maternal blood with respect to allergen specificity, level of specific IgE, and ratio of total IgE/specific IgE. Finally, there was a correlation between specific IgE and IgA in cord blood.

CONCLUSION:

Allergen-specific IgE in cord blood does not reflect intrauterine sensitization but seems to be the result of transfer of maternal IgE to the fetus.

[PubMed - indexed for MEDLINE]
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