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AIDS Res Hum Retroviruses. 2008 Mar;24(3):375-8. doi: 10.1089/aid.2007.0207.

Elevated substance P levels in HIV-infected women in comparison to HIV-negative women.

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  • 1Division of Allergy and Immunology, Department of Pediatrics, Joseph Stokes Jr. Research Institute at the Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.


Substance P and its receptor (neurokinin-1R) are potent modulators of neuroimmunoregulation and HIV/AIDS infection. We previously demonstrated that HIV-seropositive men had significantly higher substance P levels compared to uninfected controls. We now demonstrate that substance P plasma levels are significantly higher in HIV-infected women in comparison to uninfected control women.

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