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J Bacteriol. 2008 May;190(10):3489-93. doi: 10.1128/JB.00146-08. Epub 2008 Mar 7.

Topology and function of CcmD in cytochrome c maturation.

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  • 1Department of Biology, Washington University, Campus Box 1137, 1 Brookings Drive, St. Louis, MO 63130, USA.


The system I cytochrome c biogenesis pathway requires CcmD, a small polypeptide of 69 residues in Escherichia coli. Here it is shown that CcmD is a component of the CcmABC ATP-binding cassette transporter complex. CcmD is not necessary for the CcmC-dependent transfer of heme to CcmE in the periplasm or for interaction of CcmE with CcmABC. CcmD is absolutely required for the release of holo-CcmE from the CcmABCD complex. Evidence is presented that the topology of CcmD in the cytoplasmic membrane is the N terminus outside and the C terminus inside with one transmembrane domain.

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