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Pellino 3b negatively regulates interleukin-1-induced TAK1-dependent NF kappaB activation.
Xiao H, Qian W, Staschke K, Qian Y, Cui G, Deng L, Ehsani M, Wang X, Qian YW, Chen ZJ, Gilmour R, Jiang Z, Li X.
J Biol Chem. 2008 May 23;283(21):14654-64. Epub 2008 Mar 7.
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Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases.
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